Daniil Medvedev leads the record after 10 meetings.
| Surface | Rublev | Medvedev |
|---|---|---|
| Hard | 2 | 8 |
| Tournament | Round | Surface | Winner | Score |
|---|---|---|---|---|
| Hangzhou Open - Hangzhou 2026 | F | Hard | Medvedev | 7-5 6-4 |
| Nitto ATP Finals - Turin 2023 | R5 | Hard (Indoor) | Medvedev | 6-4 6-2 |
| U.S. Open - New York 2023 | QF | Hard | Medvedev | 6-4 6-3 6-4 |
| Dubai Duty Free Tennis Championships - Dubai 2023 | F | Hard | Medvedev | 6-2 6-2 |
| Nitto ATP Finals - Turin 2022 | R5 | Hard (Indoor) | Rublev | 6-7(7) 6-3 7-6(7) |
| Western & Southern Open - Cincinnati 2021 | SF | Hard | Rublev | 2-6 6-3 6-3 |
| Australian Open - Melbourne 2021 | QF | Hard | Medvedev | 7-5 6-3 6-2 |
| U.S. Open - New York 2020 | QF | Hard | Medvedev | 7-6(6) 6-3 7-6(5) |
| St. Petersburg Open - St. Petersburg 2019 | QF | Hard (Indoor) | Medvedev | 6-4 7-5 |
| Western & Southern Open - Cincinnati 2019 | QF | Hard | Medvedev | 6-2 6-3 |
Meetings are the ones on our record. Older matches may be missing.
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